Joint and muscle pain. Hormones are a strange thing, and they can affect almost any aspect of the body including your joints and muscles. When PMS is present in a woman’s body, she might suffer from joint pain and muscle pain that ranges from minor to severe. The most common areas of the body that are affected are the back, the hips, thighs, shoulders, and neck. The body releases something called prostaglandins around the time a woman’s menstrual cycle is slated to begin. This is what contributes to joint and muscle pain in women who suffer from severe PMS symptoms. There are other reasons this might occur if a woman knows it’s not time for her period to begin, and those reasons could be dangerous to a woman’s health.