Symptoms. The most common symptoms include dripping or drainage in the back of the throat, persistent heartburn, wheezing (a whistling sound, heard when breathing in), shortness of breath or a runny, stuffy nose. Some of the rare and more concerning signs include a high, prolonged fever, blood in the sputum (a mixture of saliva, mucus and, sometimes, pus), coughing up abnormal amounts of sputum, chest pain (not caused by coughing), a sudden loss of appetite, unintentional weight loss and extreme fatigue.