Treatment. The pain caused by a mild case of sciatica often decreases with time and may not require medical intervention. For those experiencing more pain and a decrease in function, doctors will generally prescribe medications and physical therapy. Pain medicine, anti-inflammatory drugs and muscle relaxants can be ordered by the doctor to help reduce pain, inflammation and muscle spasms. This can allow people to have less pain and more freedom to engage in exercise and daily living tasks. Physical therapy can also be very helpful in lessening the pain of sciatica. The physical therapist can devise a specialized exercise program to help relieve pressure on the nerve. The program will typically focus on exercises involving muscle strengthening and stretching along with aerobic activity. Spinal injections and surgery are also options for those with severe pain.