Symptoms. The symptoms of polycystic kidney disease are difficult to endure because of their severity. At first, there will be pain in the lower back where the kidneys are positioned. This pain can become excruciating if any of the cysts break open. Then, as the damage progresses from the multiplication of the cysts, blood will be seen in the urine. The abdomen will swell up too because of the immense size of the kidneys from the excess fluid that the cysts hold. So many people who have this condition lose their appetite because the pressure on their stomach causes them to feel full all the time.
